Can changing speaker cables often require adjusting speaker placement?


Just switched from Grover Huffman "EX" speaker cable to Harmonic Technology's PRO 11+ which is about 6 years old.  The Huffman cable has remarkable clarity, but can also be edgy on the top end at high volume.  The older Harmonic Tech Pro 11+ is better balanced with much greater midrange detail, and lower mids detail. Bass is outstanding and tightly controlled

MAJOR ISSUE::... with the HT speaker cable, the sound is more forward and somewhat in your face. The GH cable was less so in your face and a tad more depth 

****Therefore, do different speaker cables require adjusting speaker placement, that is, in relation to the back and side walls??? .

The speakers are Golden Ear Technology's model 7  Speakers setup was made according to instructions in manual.  However, I had to work within the parameters of the room dimensions of the long axis.  For example, speakers are 22 inches from back wall, and approx. 40 inches from sidewalls. They are slightly toed so tweeters response converges at the tip of the a triangle behind my head. BTW, I sit about 10 ft from mid point between speakers  Thank you   

sunnyjim
If your speakers are just 22 inches out from the wall behind them, that's not very much.  You probably won't get much depth with any speaker cable.
I sort of agree with Mofimadness--

I really have no idea of space limitations in your room so forgive my ignoring problems that may prevent you doing anything, but here is what I would do to optomize the sound, and perhaps correct the 'forwardness' you are hearing. 

Bring the speakers out further into the room is a big deal and might just be the best single thing you can do (mine are, for example, on the short wall 6ft out in a14x 20ft room.  But if you can getting them spread further apart that can help a lot as well. If you can't do that you can try just pointing your speakers straight ahead which will take your sweet spot well off of your speakers axis.

For example, mine are 2 feet from the side walls and toed in so the axis crosses just in front my head, and I sit about 9 ft back from the speakers. This is close to an equilateral triangle.  Sitting them closer to the side walls can increase upper bass a bit (but a lot of systems can benefit from that even if it occurs). Then I toe in the speakers until the axis crosses in front of my head which minimizes side wall sound reflections substantially. 

It is really hard to project with any certainty what will work, you just have to move stuff about in small increments until you get something that works. FWIW I think your newer cable has better long range potential for your dialing it in. But your going to have to work at it, a lot. :-)