Speaker recommendations

Thanks to all who've responded so far. I sure appreciate the effort. 
In an attempt to further specify so as to take full advantage of all this knowledge out here I will add a bit more info.
My general ear preferences tend toward the highs and away from the lows. Part of this is hearing loss and part may be personal choice bit I do find that when an equalizer is available I seem to always turn up the higher frequencies and turn down the lower ones. Bass tones to my ears seem to often overpower.
Also these theoretical new speakers kind of have to go in a fairly limited location. One foot from the end wall and two and a half feet from the sides of a 12 x16 listening room that is open at the away side to a cathedral ceiling.
Thanks again for all your past and future input.

I agree with the KEF LS50 recommendation.  I think it would be a great match.  By the way, the NAD 375BEE is an excellent integrated amp, but it's generally known a warmer amp and may not have the detailed highs that you are seeking.  Another thing to note is that the sound of the 375BEE improves dramatically when you use a set of good interconnects between the pre-out and the power-in rather than leaving the stock metal bars in the signal path.  I was stunned at the difference that this made.  You could probably get much closer to the sound you want with some good, detailed interconnects.

Last and final question for you audiophiles out there.
I  went to a stereo shop and listened to a pair of B&W CM10 speakers and  really loved them. But they were beyond my budget. I have found a used pair of B&W Matrix 802 Series 3 speakers for sale that I can afford. Before I drive the 2 1/2 hours to listen to them I was wondering how you folks think they  compare  to the  
CM 10 .
Thanks so much