I am much - but not fully - in line with Atmasphere on this, since his experience agrees with mine. Balanced is usually better. I also agree with Williewonka, and nkj. I think the quality of the cable plays a role, though, even in balanced mode. Balanced cables also perform differently in my system, although the variation in single ended cables is even greater. I am using a rather "naked" classical well-rated cable, the Kimber KCAG (single ended), in a DIY mod to make a phono cable (soldered to the mini-DIN plug at the tonearm side). I did this because I always liked the KCAG compared to various other single ended IC’s. The cable needs dressing, but even then, I can sometimes hear phones etc.it is a bit like an antenna. But aside of this it makes music in a light (should I say silvery) and airy way that I like. Nkj - I also tried a Hovland cable (single ended), yes it was nice, better tuned to the task I think, but it did not totally outperform the KCAG. I was a bit disappointed. - My experience with balanced / xlr is that there may be a price to pay, also, for the shielding, a less open and immediate sound. Not at all sure about this, just my two cent reflection.
"Why not just run balanced all the way" - my thought also - even if, in my case, the effect will be diminished by the (SE) first gain stage of the Io. - Thanks for all advice. I will certainly try both options, as soon as I get the Io back from repair. Tell you more then. In the meantime, more experiences from users of similar systems are welcome.