Your opinions on how to string 25 ft speaker cables

+1 richz.
If you should decied to twist don't forget that the wire length needs to be a bit longer.

I'm running a similar setup with similar cable, except with 2 less cables:  basically two 24' runs of 12 gauge AntiCables under the floor.  Speakers have only one set of binding posts, so this is just a true "double-run" of cable.  I went to the effort of trying this 4 different ways: cables run simply side-by-side in a "shotgun" type configuration (both conductors of one cable to the "+" terminals and both conductors of the other to the "-" terminals), cables run side-by-side in a typical bi-wire configuration ("+" conductor of both cables to the "+" terminal and "-" conductor of both cables connected to the "-" terminals), and then both of those configurations with the cables twisted together (one full twist about every 6").  Very obvious difference for the better (in this setup, and to my ears) with the bi-wire configuration -- the "shotgun" setup seemed to be a touch smoother on the top end, but robbed initial attack on transients and curtailed overall dynamics to a very noticeable degree.  The presentation got boring, if you will.  I did not notice much difference with either configuration in the twisted versus untwisted configuration.  As the twisted setup was my last trial, I just left them twisted and did not go back and untwist them for a final verification.  Happy enough with the result in that config. And the addition of the second set of cables was a very nice improvement overall -- more dynamics, more (apparent) extension in the bass, and more depth to the soundstage.

What 12 AWG cable do you have from Monoprice? Is it the clear or one of the CL rated ones that have a red and black in an outer jacket? IMHO, I would not use the clear in a crawl space.

12 gauge wire has about 340nH/ft inductance. It is 17uH for 2x25ft wire and represents impedance of 2.14 ohm at 20kHz. Bringing wires closer reduces inductance, twisting reduces it further.

As for high levels - levels for bass peaks will be in tens of volts, but levels for the soft tweeter sounds might be in milivolts. Any wire hanging is an antenna that feeds electrical noise into the amp. Speaker output post is an input for negative feedback while output impedance is low only for low frequencies.

Twisting pitch should be much smaller than the wavelength of the highest frequency we want to defeat. Wavelength of common 2.4GHz is 4.9".
1" twist pitch should be sufficient.

Thank you all for your thoughts. I will twist, and shout back at ya.