I'm running a Polk sub that accepts the outputs from both a receiver (mono out) and my main 'pile' (L&R) without any issues.
I don't run both at the same time, but haven't tried it either. *L* I could send two entirely different program sources to the Polk which could be amusing to listen to for awhile...
I'd think it'd rattle itself over to me and inquire if I'm pissed at it, or merely on drugs. ;)