Epos Elan 10s or Epos Epic 1s with one of the new Yamaha integrateds would make a great match for that room size. You'd have plenty left over for some heavy, good quality stands, which impact the sound more than you might assume.
I've owned the Epic 2 speakers (larger and probably too much bass for your room) for 4 years and they compete well with most speakers under $3K. Of course, speakers all come down to personal taste, but these Epos models are great all rounders IMO, and don't have any blatant weaknesses.