It varies from system to system, of course. But more often than not the importance of a line-level analog interconnect can be expected to be greatest where the output impedance of the component providing the signal into the cable is highest, especially if there is a considerable difference between the output impedances of the two components. Sensitivity to cable differences will also tend to increase as cable length increases, and will often tend to be greater if the cables are unbalanced as opposed to balanced.
Regards,
-- Al
Regards,
-- Al