By *set up* are you referring specifically to the EQ I used, or by *set up* are you including any system that measures flat at the listening position?Any system, unless the measurement equipment is extremely sophisticated and has response characteristics in the time domain that closely correspond to those of our hearing mechanisms.
In other words, a system that produces measured flat frequency response at the listening position, based on test tones, will give equal weight to sound that arrives via the direct path from speakers to listening position, and sound that arrives via reflected paths from walls and furniture.
But our ears don't work that way -- consider the Haas Effect, for example, which describes the fact that, within certain limits, our hearing mechanisms give greater emphasis to early arriving sounds than to later arriving sounds (which are presumably reflections).
And adding to that is the fact that even in the frequency domain the directional characteristics of our ears are unlikely to match those of the measuring microphone. So the microphone will "hear" reflections from side walls, for example, differently than our ears will.
Best regards,
-- Al