i would suggest that because speaker cable affects the sound reproduced by the speakers from the receiver generating the test tones that recalibration when changing those is necessary. power cord to the amp would affect the sound as well. ic's are farther along the soundpath chain and therefor would not affect calibration. also, in regards to bass management, audysee merely provides the software to the receiver manufacturer who then decides how to implement it. for instance, in my marantz, they decided to set any speaker that can reach 60hz as "large". clearly this is incorrect, but it may still sound best and integrate optimally with your sub. many suggest taking the lowest frequency repro of your speakers and adding twenty to it and set crossover there. for me, (totem dreamcatchers 57hz+/-) audysee set them as large and crossover at 60hz. i changed it to recommended spec(small and cross @ 80). i found that to sound thin, so i just changed the speakers to small and left the crossover at 60hz, this way the sub takes over ANYTHING below 60. now i have good midrange punch and liquidity, with bottom end oomph. so, in the end, play around with the crossover and large/small setting to find what sounds best to you in your room with your system.