Well, I don't think the man is asking about this kind of extreme tuning that Michael is talking about. I certainly wouldn't tune for every recording just as I don't adjust VTA for every record but fine tuning the complete system to achieve the best possible compromise is worth the effort and a true audiophile endeavor. But first the system must be complete, both active and passive components. In a sense, there are no passive components, cables and power cords are also very active. How to achieve the system completeness ? Well, I don't have an answer, you got to experiment, to listen and to have audiophile instinct. System is complete when if you insert any new components in it, as good as it might be by itself, the sound you get is off the balance and out of tune, in other words - worse overall even if it might be better in certain aspects.