Top Notch Desktop System

If you can place them in the corners, I would think about Vandersteen VLR's. Great bass response when properly placed, and a nice non fatiguing sound reproduction, as well.
Bob

I use Harbeth P3ESR in my desktop system. (I have them on the inexpensive DS2 rubber stands from Audioengine.) After having the Harbeths for a while, I added a B&W 10" subwoofer (ASW610) I found used on Audiogon. This makes a great desktop system!

I did try the KEF LS50s for this application and found they did not integrate well in such nearfield listening. In the nearfield (and even in the midfield), I find the LS50 too brash for my taste. It’s possible KEF refined the response in the wireless version.

P.S. You mentioned "all-in-one." Before the Harbeths, I used Audioengine A5+ powered speakers. They are incredibly good for the price! So maybe consider them, and also the new Vanatoo Transparent One Encore, which sounded terrific to me at AXPONA. I believe either one is available with a trial period.

The KEF speakers are tonally on the cool side, which some love and others don’t. 

Bob, thank you for mentioning the VLRs.  I will read about them.  

Mike, the Harbeths were on my list, but I forgot to include them in my post.  Thanks for the information about them.  

The KEF's do seem to be a little polarizing, especially in the near field.