Duke we take a systematic approach which has been honed by having tons of gear incomming and outgoing.
There are the intrinsic attriubtes of the product and then there are the issues in matching the one product to the rest of the products and then then the room.
The issue here is to figure out is it the room, the combination of this set of speakers with the OP's particular set of matching products.
Sometimes it is a simple fix, we setup our Blades on one side of our big showroom opposite another set of reference speakers at the time, and the Blades sounded horrible, the space was too live in that part of the room, went to Pier One and bought a boat load of different sized pillows which we then piled up behind the loudspeaker and boom the hardenss that was the room feeding back went away completely. Not exactly the look we wanted but the system sounded good.
We have used this trick at Audio Shows as well.
So for the OP he has a few options one try a different set of speakers in the same space with the same gear and see if that is moving in the right direction, then to try a match with different electronics, digital and cabling and of course room tuning.
Without seeing pictures of the room and knowing exactly the matching gear we are both firing blindly here.
Dave and Troy
Audio Doctor NJ