I'm trying out a single Syzygy 10" subwoofer, with a stereo system on a concrete slab and engineered red oak flooring. The room is not exactly rectangular, but it's basically 18' W X 28' L X 9' H.
1)The single sub sounds best when it is adjacent to or between my stereo speakers, but the exact location does not make a lasting difference. (I can move the sub and think the new position is better, but the next day I can move it back with the same effect--I can't find a single best location.
2) There is a difference in the sound between forward firing and down firing, but it is more about the music than a single best presentation. For rock, forward-firing in-your-face bass delivers, but that doesn't mean it's better overall.
3) It is a fairly advanced sub which reads and graphs the room and is controlled by a smart-phone (which means one can listen anywhere in the room). The sub itself may be optimizable for the room, but it does not blend well with the stereo speakers. I can get drama--not a problem for Star Wars--but it's annoying for serious listening.
4) The experience has helped me understand why multiple subs would do better than one, and how the placement of multiple subs would be easier than one.
5) At the same time the experience has helped me understand how better quality--"faster, taut, deeper, and more musical" could help, and probably more than equalization.