Just to be clear, we are talking about the output of the cartridge in terms of its signal voltage. We are not talking about the input sensitivity of a cartridge, which is a term that almost makes no sense. Sorry for being pedantic, but if you want to make yourself understood, it is good to get the terminology right.I agree with what everyone else said, try all three settings and go with what you like best. Often the lowest possible gain setting will sound best because of less circuitry in the pathway.