HI,
When output tubes are difficult to bias then is a good time to replace. That will happen before losing dynamics, highs, bass and sounding muddy. You know that end of service life is close and it is better to have a spare set to check it. Better safe than leave them on till last moment. Visual check is not always the best guide but if the getters are not shiny any more and the silver layer at top of glass has gone off is a sign for replacement.
When output tubes are difficult to bias then is a good time to replace. That will happen before losing dynamics, highs, bass and sounding muddy. You know that end of service life is close and it is better to have a spare set to check it. Better safe than leave them on till last moment. Visual check is not always the best guide but if the getters are not shiny any more and the silver layer at top of glass has gone off is a sign for replacement.