The contacts on the end of the fuse make a difference too- which has led to the idea that fuses are directional (they aren’t). Its just that sometimes the fuse sits better in its holder if you turn it around (although by simply rotating the fuse you can get the same effect, which can be seen by a reduced voltage drop across the fuseholder).
But even this Ralph is null and void also, when the equipment has regulated supplies, as many "directional fusers" claim differences in fuse direction on their preamps and source equipment with regulated supplies.
As for them blowing for no reason, if indeed they do cryo them, this "can" make the fuse element more fragile harder/stiffer and suspect to de-rating it’s amperage and hence (blow earlier), a bit the opposite to what happens to us the older we get.
"IT"S ALL JUST SNAKE OIL"!!
Cheers George