I use my non-meta LS50's with very neutral gear and have zero fatigue. I listen a lot of hours while I work.

The speakers will go into storage on Saturday to move in my new speakers, but I will never sell them, just love them. 
Yup no fatigue with old Ls 50s and not expecting any with the metas either based on limited audition and reviews to date. 
I’m going off of memory but I believe the original LS50s have a bump around 12k that could be bright to those under the age of say 35. 
I haven't heard the meta yet but I found the original LS50 to be fatiguing because of the extra energy mostly around 2k, I applied a few filters based on the Soundstage measurements to make them more neutral and they were amazing with no fatigue. 

The new meta LS50 have detailed measurements in their whitepaper and they appear to be much smoother in the highs with no peaks like the original LS50 so I wouldn't expect them to be fatiguing at all . 

Hi all,

I just bought a pair of these speakers.  I have $3k to spend on the rest of the system - what are the recommendations?  Should I go the Naim/Cambridge/NAD route, or should I go separates?  I enjoy critical listening, but most will be casual with the speakers in my large-ish office.  I used to have a krell monoblock system so I appreciate good sound.  Would be nice to get as much as I can.  

 

Thanks!