This is a tough one and it would take a book to explore all the possibilities but let me tell you what I do in these cases. I pull the equipment off the rack and set everything on the floor. Then I put the most basic system together. Amp, speakers, source, etc. Then I use my ground breaking RCA interconnects or a ground breaking power cord/device to isolate the problem. My toughest case so far was an ungrounded preamp that would hum. Turned out if I reversed the two prong plug, the hum went away. Drove me nuts but I was totally relieved when I solved the problem.
So...good luck and just get down and dirty and work the issues until you can with certainty identify the offending hook-up or component.
So...good luck and just get down and dirty and work the issues until you can with certainty identify the offending hook-up or component.