Placement of Dual Powered Subs with Tower Speakers

Yes, but not the same way.  When you place your main speakers you place them for symmetry above all.  In 2 sub setups symmetry is often a bad idea.

You want to place the first sub as ideal as you can, then place the second so it fills in thee nodes left behind.

Consider the Room EQ Wizard’s room simulator as a useful guide.

the first sub is ideally placed, second sub facing straight ahead, or possibly on the side ?

By placement I mean location in the room. That takes some effort.

Turning it to the side, or away from the listener, etc. usually has very little benefit, so orient them in the most aesthetically pleasing manner.

You want to locate the first sub so as to have the smoothest measured response, with minimal anti-modes (big dips) and small peaks. Then locate the second sub in the room so as to complement and smooth it all out. 

Turning your sub around won't really help this. :)