In practice the room’s layout usually imposes constraints, and from there one just applies the basic principle of maximizing spacing and asymmetry. Like I recently did a layout for someone who wanted to avoid wires crossing walkways, and one quadrant of the room was off limits. Those were the constraints, and from there it was pretty straightforward.
@audiokinesis
Well, color me surprised this works as well as you have experienced!! It feels a little too much like relying on serendipity for me to have every thoguht to try it this way. :-)