There is, theoretically, a place in a room where speakers interface at an acoustic optimum. A computer program can help find those locations, but there are too many variables for the procedure to be absolutely perfect. Human hearing being what it is, we will want to final-tweak them to the location where our ears tell us that they sound best.
Once you find what seems, to your ears, to be the ideal location, it's probably best to do some extensive listening after each component change to allow your ears to adjust. Unless there has been a change in the acoustical environment of the room (by adding a piece of furniture, etc.), optimum speaker location really shouldn't change.
Once you find what seems, to your ears, to be the ideal location, it's probably best to do some extensive listening after each component change to allow your ears to adjust. Unless there has been a change in the acoustical environment of the room (by adding a piece of furniture, etc.), optimum speaker location really shouldn't change.