I have a pair of Air Tight MSM-1 Bonsais that would fit well on a desk. ( No I'm not selling them! ) They are single-driver so they work well nearfield, but they can also fill a room. To get much sound below 100Hz you'd need a sub, but that's true of any small box unless the designer has skewed the natural response curve.
The Bonsais have amazing resolution and 'live' quality. For my 2 cents, look into single-driver designs generally for your application.
The Bonsais have amazing resolution and 'live' quality. For my 2 cents, look into single-driver designs generally for your application.