I never leave tube amps on unattended, preamps and other tubed equipment may be ok, never tube amp. My two 845 SET amp owner's manuals specifically state amps should not be played more than eight hours continuously. Push pulls and lower powered SET don't generally have this limitation.
Still, I never leave any tube amp unattended; if a power tube red plates you're going to have a nice repair bill.
I always just listen through burn in with tube amps, can be at background volumes and my attention on other things, but I'm always in room.