I currently have a Node 2i into an amp. The outputs of the amp go to a Niles impedance matching unit which allows me to run 8 pairs of speakers from 1 amp, as long as the amp has enough power.
This in turn is wired to speakers all over my house. The Blue OS will control master volume but each room really should have independent controls. I put a niles in wall volume in each room to adjust levels or turn it off.
This works seamlessly and sounds great. The Node is nice and with the right amp and speakers it sounds even better.