Using 2 different brands of interconnects?

It depends is always the right answer. But as my equipmemt got better and better I zeroed in on a brand that consistently performed the best for me (Transparent). I have always suspected that combining a warm interconnect and a cold / detailed one serially would act as a filter... so that in the limit it would be a bad idea. 
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Also, comparisons take time and after hundreds of hours of comparisons over decades... I really want to enjoy listening to music, not listening to my system. So, now I have a trusted brand that I know complements my equipment (ARC, Sonus Faber, and Transperant is a known compliment which I discovered independently) and and only requires a decision by me on how much to pay.

If you have yet to learn what you are specifically looking for?  (that can take years).. Enjoy.  Its like using two different coffee beans when grinding to make coffee.

@genez 
“If you have yet to learn what you are specifically looking for?”
This is very true. At first I wanted bass, then the magic of electrostatic, then more accurate and natural, finally musical. So, what I wanted changed over the decades.

$100.00 cables sounds like junk just pretend it sounds good.Dream on!!

^^^
from the man who asked

I now have a low level buzzing coming out of my tweeters even when i am in mute. It happens even with the amp on and preamp off never had this before. Any suggestions would be great. Thanks in advance. [in  Low level buzzing coming from tweeters. | Audiogon Discussion Forum]

and then said

Got balanced cables as i now have a balanced preamp Purist made my single ended cables balanced buzzing is now gone. I will now used balanced always and use Purist always. Thanks!!!!

Reading between the lines, one could conclude ebm is not an engineer...