There's a chap called Mike Lavigne who has an absolute top flight system and is very approachable. I asked him the question and he said that after a certain stage in a turntable it's the improvements in the arm that are the most significant. Cartridges IMHO are often very subjective - liken it to a lens filter that may highlight some aspects better than others. When speaking to quite a few cartridge dealers and repairers of note the impression I get is that above £3000 is about getting the story of some fisherman that makes swords after reading to his grandchildren who only makes cartridges when meditating... I haven't heard enough to say one way or the other.
@chakster as a joke question I bought a JVC QL 10 with UA arm in mint condition for £400 - is a £10,000 cartridge wasted on it?