My floor-standing speakers went to our HT room. I ordered W-B Vertex that are 2-way on integrated stand mounted loudspeakers which are -2dB at 44Hz. The mid/base driver is direct coupled to the amplifier with a 2nd order crossover to the tweeter at 5K Hz. Imaging, soundstage, dynamics and details are quite amazing. I've been augmenting the bass with a JL Audio f112. I play both vinyl and digital music files.
I just took delivery of the W-B Torus system last evening and will unpack them today. This should solve any integration issues and improve an already overachieving system.
So, the short answer is definitely yes, moving to a 2-way speaker system with subs can be much more desirable. It just depends on the acoustic space and the way you execute it.