Good insights.
It seems to me though you're leaving out one scenario, namely that pairing the larger full-range speaker (in your case the Spendor SP100 R2's) with a pair of subs. Have you tried out that combination with the REL's of yours?
This is my own preference and actual speaker setup; large floor standing (semi-)full range main speakers coupled to a pair of large (20 cf. volume per cab) tapped horn subs. That's a total of four 15" drivers covering the range of roughly 85 to 600Hz, and two tapped horn-loaded 15" drivers (effectively adding up to the equivalence of four to five 15" drivers in air displacement area) reproducing ~20 to 85Hz. Whilst my main speakers are not full-range strictly speaking (35-40Hz is their lower, stand-alone limit) what matters is that four 15" (high efficiency) drivers are used in outlined region and what this means for the reproduction of this vital frequency spectrum. Important also is that they're high-passed below ~85Hz, meaning they are relieved of LF which cleans up their used range and adds further headroom.
To my ears nothing beats large main speakers coupled to a pair of large subs. This combination alone leaves many variations to be explored though to fit many different needs and goals.