I have several subs but so far the only method that powers them with a line-level signal is using a Y splitter coming from the DSP unit's analog line level outputs. In this mode I cannot use a high-pass filter on my mains to relieve them of bass 60 and under +/- as it feeds the subs as well.
That would be my preferred way to do it but if you want to split the lows from the highs, go into the sub, then out of the sub to your mains amp.