You can start with 80Hz crossover and later try higher or lower.
Don't know the Vandersteen sub nor M12, but do have multichannel with two F12 as subs. In my experience leaving the bottom to subs is better, provided integration is done right. To do this, in my experience measurement equipment is indispensable and advanced digital xo is very important too.
One step at a time is best. Otherwise the new many variables can get overwhelming.