I am a true believer in true balanced. The Ref 6 was optimized for running balanced and even though some may disagree, running true balanced is not only about hum rejection. Since my Ref 150 SE blew, I have been using my Ampsandsound Nautilus which offers both fake-balanced (transformer coupled since on SET amp can not by definition be balanced) and SE inputs. I have tried both. Even with the transformer coupled "balanced" inputs, running XLR's rather than RCA's sounds much better. My XLR's are Cardas Clear Beyond. My RCA'S are Analysis Plus Silver Apex. No doubt "it all depends" but with the Ref 6 the scary-real soundstage depth, height, and width collapses with RCA's. Bass tonality suffers too.
As another example, I have a Luxman 750u headphone amp. It needed a minor repair (internal fuse). The tech who repaired if for me, Steven Leckrone, emphasized to me that the Luxman circuitry on his test bench made it clear to him that running balanced from input to output (the headphones) was essential for best sound.