@steverrino The short answer is you'll need both because native DSD can usually only be transmitted over USB or I2s.
If you only use AES/EBU you'll need to listen to DSD in DOP, which is over 90% as good as DSD but it does lack the sparkle of DSD.
You'll also find that PCM formats FLAC and WAV will sound differently over USB and AES/EBU.
No easy answers.