My experiences.
Poured concrete basement, pad, carpet.
1. Vandersteen 2ce Sig IIs. Had spikes, tried IsoAcoustics Gaia's. The Gaia's really sucked the life out of the speaker especially the bass. Now let me say that I did hear a benefit with using IsoAcoustics Oreas with the integrated amplifier that I was using at the time, so I do have an open mind on decoupling. Anyway, I returned the Gaia's and went back to spikes on the Vandersteen's. The sound immediately was back to good.
2. Wilson WATT/Puppy 6. I have the stock spikes on these and have no issue with the sound. Not tempted to try IsoAcoustics on these at the moment.
Anyway, just my experiences.