Without cross checking with other tubes, I wouldn't run the amplifier. There may be a problem with the screen voltage being out of spec (which can cause tube failure, distortion, and/or inability to increase or decrease plate current to spec). The amp will probably continue to eat tubes on that socket.
A lot of times it is bad solder joints that causes these kinds of problems after a good amount of time of normal operation -- and simply reflowing solder joints solves the problem.