I recognize that not everything in audio is predictable and also that different does not always mean better to all listeners. That being said, my own biases lead me to try to make full use of the USB to I2S in the Musetec with the advantages that its designer has given us. These advantages include an excellent USB board, three exceptional clocks, a sophisticated battery-like DC power supply, and the shortest possible I2S connection.
At one point in my own DAC adventure I looked carefully into devices that went directly from ethernet to I2S. Such a device would bypass any USB connections, cables, etc. I quickly learned that while such a device might provide a theoretical benefit, in practice it would likely provide less than I already had. Beekhuyzen got the same result.
So my own road has been to try to provide very high quality USB signal into the DAC. I keep my media on a NAS and I use JRiver on a small lap-top. This has eventually led me to digital bridges (ethernet in, USB out) run as DLNA devices. My first was using an Oppo 501 (though coax out) much as car123 was using his Aurender, the only difference perhaps being the DLNA control through JRiver. Not saying here that the Oppo is equal to the Aurender, but each used in this very odd way they might be comparable.
I soon discovered that this route into the DAC could be improved dramatically using devices more sophisticated, and with USB out, than using a small part of a DAC-streamer. I eventually wound up with an SOtM sMS-200ultra Neo and an SBooster power supply for it. Under the control of JRiver this device reclocks and otherwise decrapifies the data from the NAS and sends it directly to the DAC. It is hardly the last word in devices performing this function, but I am delighted with it. Furthermore, it makes full use of what the Musetec provides.
The other part of this puzzle is the section of a USB cable, and they can be very, very different. More on this later, with at least one surprising result.