Generally speaking a computer, like your Dell, is a noise machine and running USB straight out to a DAC is never advised. Sound will definitely be compromised. Some special "audio" computers (or mother boards) are offered (as recently by SOtM) and there are programmatic fixes that purport to quiet a computer down by shutting off most of its services. Otherwise, and for most people, there are ways of cleaning up the digital signal as it leaves the computer (which we sometimes refer to as "decrapifiers"). Other ways of, effectively, getting the music out of the computer can either use DLNA as I do, or use some kind of mini-computer device such as a unit incorporating a Raspberry Pi or similar board and divorcing the sound from the computer. They may, for ex., have ethernet in and USB out. just like your computer.
This goes beyond digital, but a good preamp should not be viewed as a compromise, IMO. I’ll call upon other contributors to this thread to elaborate. I think some have tried using a DAC (including this DAC) straight through and have found the addition of a preamp to enhance SQ, as well as giving more control over what you hear. Plus it restores full dynamics.
As for getting your computer out of the direct digital chain to your DACs, there are as many solutions as there are audiophiles. I know this thread is very long, but all through it folks have written about their set-ups. I use an SOtM unit as a DLNA device because I like using JRiver on my computer, but it could also be used as a stand alone with the Roon Ready or Squeezelight programs within. Again, perhaps others will chime in with advice here.
The better your digital system and your system in general, the better you will be able to hear differences among the various DACs that you have, and the Musetec that is on its way.