My speakers are home-brew, look like Klipsch Lascala on steroids, average sensitivity is 105dB and I tri-amp with an analogue active crossover (subs, bass/low mids, mids/treble)
For me the micro and macro dynamics associated with high sensitivity (100dB+) is something I could never do without, and being able to use very low power amps is a definite advantage
BUT
-big horn systems image differently, you either love it or hate it
-ANY noise or distortion will be MAGNIFIED and unbearable - this is real - any RFI / EMI, any noise on the AC lines, anything from the outside world (or from your electronics) that would mostly stay hidden on a low sensitivity system will be exposed and you will have to deal with it or live with it!
-caution with gain structure is important, otherwise say hello to noise (see above remark) and hello to all the issues some preamps can have when used with the volume potentiometer at the lowest settings (bad stereo tracking, loss of dynamics and definition, etc) YMMV depending on the quality of your preamp(section), but shouldn’t be overlooked