All my equipment is balanced (Audio Research Reference) and Audio Research recommends using balanced. I have tried both. I was unable to hear a substantial difference. Since, more and more manufacturers are headed that way (I think), I went ahead and switched over all my interconnects. More as a just in case thing.
If my system was not in what I consider it’s apex state, I would not have changed over. I would have applied the money to improving components. There may be other components more sensitive to the interconnect used. I am sure Audio Research put a lot of effort into converting the signal from balanced to unbalanced… this is audiophile stuff. They want every input and output to sound good, but extra conversion is never a good thing and tiny differences add up to making an impact. So, it depends on where you are in system building if you should worry too much about this.