I have both the Ref 150 SE and Ref 80S with a Ref 6. The two amps have a very similar presentation. They both need a TON of break-in. 500-800 hours. I was a bit let down by the brand new Ref 80S at first. I was not patient enough. I can't prove this but I believe it is not just hours but also how many times it has been cycled on and off that accomplishes complete burn-in. ARC says many hours are needed in the manuals.
I am sure you know this but the quality of the IC's between your Ref 6 and amps will be crucial. I prefer Cardas Clear Beyond XLR's. Again, ARC emphasizes the quality of the IC's in the manual.