@thyname It's interesting he mentions "galvanically isolated" for DAC's to "clean up and isolate noise", since doing so introduces a transformer or capacitor in the USB chain, which can change the phase of the signal. But it hardly matters because this is the analog side of the signal, which is not used directly by the DAC.
Finally, all but the cheapest USB hubs are already "galvanically isolated" to ensure an accurate clock signal on the downstream USB ports, so I'm not sure where's he's going with the entire message.