Unfortunately, revising the driver away from the usual single 12AU7 means another hole in the chassis, and a pair of octal sockets at that. And split power supplies means another power transformer and rectifiers, although it relaxes the endless search for Holy Grail rectifiers. When an amp is that sensitive to rectifier choice, frankly, there is a design error lurking in there somewhere.
Somewhat counter-intuitively, splitting the power supplies front to back sounds better than isolated stereo power supplies, where the gain is fairly minor. The front to back isolation is not minor. Another counter-intuitive thing is PP amps benefit more from power supply isolation than SE amps.
As for inverters, the split-load inverter plus input tube uses two sections, while Mullard and the floating paraphase use three sections. And the last two sections can be octal medium-power tubes, not a single 12AU7.
This will change the forward gain of the amplifier, not by by much, but some. Probably a few dB less gain thanks to different and lower-mu drivers. Maybe a small trim in the feedback network, but less gain is easy to adjust for (unlike more gain).
In practical terms, a new chassis. Sorry. Those old amps were engineered down to the last inch, with no room to spare, and not one part wasted. Flip one upside-down and the parts in there are really, really tight. Too tight, and prone to overheating, which does no favors to the capacitors.
Most of the engineering effort in the Golden Age, even for Marantz and McIntosh, was simply watts-per-dollar, and keeping chassis size down as a secondary goal. In the late Sixties, the Crown DC300 and Phase Linear 700 blew the watts-per-dollar tube amps out of the water, and forced them into the audiophile market, where they remain today.