I used successfully use a single sub for about 15 years.
With only one sub, it's important to remove the sub range from the mains. AND have sufficient drive from the sub.
Most subs have inadequate controls to integrate properly. You must have variable crossover frequency and slopes, continuous phase and polarity inversion.
You can get away with a less capable sub by setting the controls to minimal, e.g. highest crossover and using miniDSP or other capable crossover. I do not recommend using the miniDSP internal A/D so either feed it digitally or only use it for the low end only, feeding the mains with a passive analog XO to roll the bottom octave @ 6dB/octave.
See ieLogical SubterraneanHomesickBlues. There useful links for room analysis and other information.