$50k - $80k Budget…Opinions please.

Take your time.  Pick speakers first.  Get what you like.  Look at Sonus Faber, B&W 

Magico, Rockport, Vinberg (some great reviews) 

I recently started the upgrade path and went with Sonus Faber found a fantastic Demo pair.   I have an Anthem P5 and it still sounds great much better than people give it credit. 

Then decide on your source or sources.   I'd recommend to look at a really good 

Integrated especially if theater bypass is something you might want to do in the future.

Im looking at Boulder amp 866 and Gryphon Diablo 300 

Both have very good DAC streamers.   Simaudio Moon also makes great gear. 

Have fun.  

@toddcowles Consider running 3 dedicated 20 amp lines. 2 for mono's/subs on each side and 1 for your sources and other rack gear. With this large of a room, you may even consider doing a couple more around the room if a 2 channel/theatre combo is of any potential interest in the future. Seems overkill now, but just wait..I don't think there is a better ROI on any investment in this hobby than clean, dedicated power.

Reviewing this string it dawned on me, if I was to do over from scratch I would actively find a Shindo system and see if that would inspire my choice of direction. I have never heard one, but always have wanted to. 

Yah room is important  but maybe you can't do anything to the room.  Obviously, you had the Harbeth in the old system, and that worked out fine.  I have been in your shoes twice in the last 4 years.  I did travel around the country to visit areas where there are a lot of dealers and also attend shows.  

The main priority is finding a speaker that you really love and it will probably be different than Harbeth.  You are probably going to be looking at speakers in the $20-35k price range.  All of the other components are a piece of cake after the speakers.  If you find a speaker you really like, see if any are available on the used market.

I once bought amps before a speaker.  What a major mistake.  I ended up having to sell the amps and never played them.  Buy speakers first.  

Is Soul Note making the world’s best sounding gear on the Planet now ? 🤔

https://www.youtube.com/watch?v=5KNtDsGKLwA

 If you can't afford this Soul Note Reference System they just came out with the new Soul Note A3 Integrated amp.. Major-Breakthrough for Integrated amps 

https://www.youtube.com/watch?v=mCdfv41PE3Y