I do this in my home using ROON and Powerline adapters for multiple rooms.
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I also use fibre optic at the last few feet just before my DAC to clean up any gremlins showing up in the chain.
The only issue with this, and likely not a concern for almost everyone, is do not put the ROON core server on the side of the PowerLine gear if you are streaming hi-res. The best place to put the ROON core in close to the router or anywhere with a direct Ethernet connect to the router. The bandwidth on the Ethernet is much higher than the PowerLine. Listening to the hi-res on the PowerLine side is fine if the Core server is on the Ethernet side.
The sound I have on each ROON endpoint is fabulous. I only do fibre streaming, but use copper to get me to the fibre.