Change the output tubes when the silver getter flash starts turning brown.
for arc tube amps and avoiding the ’destructive protection’ the op seeks to avoid, this is bad advice
In general Audio Research recommends changing/replacing output tubes in their amplifiers every 2000 hours. Assuming you have the owner’s manual, you should be able to confirm same. Another suggestion would be to periodically check the individual output tube bias.
this is good advice
i understand in the case of the op’s amplifier using sooo many output tubes, i would suggest perhaps stretching the hours to 2500, maybe 3000... but check biasing often... when certain tubes or pair/bank starts to ask for more bias, it is a sign they are getting closer to going bad
i would also advise the op to make sure the amp gets excellent ventilation -- big impact on tube life in my experience