Maybe. I’ve only rarely heard any tubes acting microphonics in power amps, and only for very old NOS tubes in the V1 / input slots. Amps are very far downstream in the gain structure, so microphonics are rarely an issue. Tube preamps and phono stages are a different story.
Anyways, I’ve had a few different tube power amps right besides my speakers. Never in front, but I’ve had them on bare floor, spikes, hockey pucks, isolation feet and even expensive $3K isolation shelves. Never heard that much difference from the isolation, sorry. I play loud too. Swapping the AMPS themselves, however, is always a hugely audible difference.