I agree with most that dynamic range and ultimate volume levels might be the biggest concern. Though as has been already pointed out, often times (though not always) proper amplification can go a long way in negating that concern. Another issue is frequency response, and whether the room can handle it. Yet another issue is how well a given loudspeaker can present a satisfying soundstage and imaging. Now this last item might be more of an issue to those that listen to music that is recorded in such a manner as to preserve it, and less so if the music is not recorded with much concern for these matters. IME, classical music is more often likely to be in first category and pop music more likely to be in the second category.