A Mullard PP 300B works as follows: input tube direct-coupled to a long-tail pair (or CCS) of triode-connected 6V6 drivers. These in turn are connected to a PP interstage transformer with a modest step-up ratio, between 1:1.4 and 1:2. The interstage then drives the PP 300B grids. This would be a non-feedback amplifier, so good power supplies are required. I would imagine a number of the PP 300B amplifiers already on the market use this topology.
I suggested this earlier in this thread; and added to it that with the input circuit also being differential there is additional benefit. A fully differential circuit has harmonic cancellation at every stage of gain; not just at the output. This results in the 3rd harmonic being dominant; it is treated much like the 2nd by the human ear in that its innocuous. But compared to an amp that does not use this topology, the 3rd is at a lower amplitude, and succeeding harmonics fall off at a faster rate (than seen in an SET) on an exponential curve. So the 3rd is thus more effective at masking higher orders and since distortion is lower, the circuit can be smoother and more transparent.