Distortion with SET amps in particular goes up quickly . My understanding is it’s best to not overdrive them which can happen easily with harder to drive speakers. Efficiency and how hard to drive are not the same thing. Efficient speakers may go louder but if impedance is low especially at lower frequencies they can still be hard to drive properly. The result is distortion. Set and tube amps both soft clip and introduce less offensive orders of distortion when overdriven so things may still sound very listenable and even good in some cases with some recordings.
But bottom line you never want to overdrive any amp for best results . Flea power SETs are the most easily overdriven.