A while back ago @james633 sent me a link to an article about setting up monitors, and this is what the article had to say about setting up subs:
"At low frequencies, it is crucial that the most fundamental room modes are equally excited. Using a single subwoofer, a placement along the front wall, slightly off-centre from the room's middle axis is recommended. Using two or four subwoofers around the room is one option to even out the room mode excitations.
"Placing a subwoofer at a wall or in a corner produces the highest low frequency output. At low frequencies, the flattest response can be achieved when the room mode resonances are equally excited. A single subwoofer is usually placed along the front wall, slightly off-centre from the room’s middle axis. Two subwoofers may be a good solution to produce and even flatter response. Note that during level calibration, the subwoofer output level is set at the same level than the main monitor system."
But unfortunately, finding the ideal position for a sub is probably like positioning speakers--trial and error.